| You are probably
aware that the anti-arrhythmic drug Cordarone® (amiodarone)
is often associated with corneal changes that do not cause visual
dysfunction or vision loss. A recent addition to the package
insert of Cordarone® indicates an association between use
of the drug and the development of an optic neuropathy that
can lead to profound vision loss.
It
should be emphasized that a cause and effect relationship
between Cordarone® use and the development of an optic
neuropathy has not been proven to date. However, multiple
case reports in the literature have suggested an association
between the use of this drug and the development of an optic
neuropathy. The new package insert indicates that regular
ophthalmic examinations, including dilated fundoscopic evaluations,
are recommended for patients using Cordarone®. It is not
clear whether the appearance of an optic neuropathy is an
absolute indication for discontinuing the drug. This reflects
the fact that Cordarone® is usually reserved for treating
life-threatening ventricular arrhythmias.
We hope that this updated information
is helpful to you. As always, please do not hesitate to contact
our office if you have any questions concerning the issue
of Cordarone® use and the potential for visual dysfunction.
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